butabarbital will lessen the level or result of midazolam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.butabarbital will decrease the extent or impact of oliceridine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe. If coadministration that has a CYP3A4 inducer is critical, take into acc